{"id":150,"date":"2023-01-06T00:50:03","date_gmt":"2023-01-06T00:50:03","guid":{"rendered":"http:\/\/localhost:8888\/website\/?page_id=150"},"modified":"2026-09-03T20:15:34","modified_gmt":"2026-09-03T20:15:34","slug":"publications","status":"publish","type":"page","link":"https:\/\/samarasinghelab.com\/?page_id=150","title":{"rendered":"Publications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"150\" class=\"elementor elementor-150\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-407d5f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"407d5f1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0808bc3\" data-id=\"0808bc3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ef284d elementor-widget elementor-widget-heading\" data-id=\"6ef284d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.9.2 - 21-12-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">PUBLICATIONS<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fcf9426 elementor-widget elementor-widget-text-editor\" data-id=\"fcf9426\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.9.2 - 21-12-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><span style=\"font-weight: 400;\">Toker, D., McCrimmon, CM., Cao, Q., Pandey, A., Guzman, A., Shriram, A., Hudson, A., Monti, MM., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. Human Brain Assembloids Model Anesthetic-Induced Neural Dynamics. <\/span><i><span style=\"font-weight: 400;\">British Journal of Anaesthesia<\/span><\/i><span style=\"font-weight: 400;\">. Accepted July 2026.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Guzman, AR., McCrimmon, CM., Toker, D., Novitch, BG., Watanabe, M., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. Protocol for Characterization of Spatiotemporal Network Dynamics in Cortical and Hippocampal Assembloids. <\/span><i><span style=\"font-weight: 400;\">STAR Protoc<\/span><\/i><span style=\"font-weight: 400;\">. Epub 2026 Mar 27;7(2):104463. PMID: 41904955.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">McCrimmon, CM., Toker, D., Pahos, M., Lozano, K., Lin, JJ., Parent, J., Tidball, A., Zheng, J., Molnar, L., Mody, I., Novitch, BG., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. Modeling cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability. <\/span><i><span style=\"font-weight: 400;\">Cell Rep<\/span><\/i><span style=\"font-weight: 400;\">. Epub 2025 Sep 23;44(9):116217.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Atamian, A., Birtele, M., Hosseini, N., Nguyen, T., Seth, A., Del Dosso, A., Paul, S., Tedeschi, N., Taylor, R., Coba, MP., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Lois, C., and Quadratto, G. Human cerebellar organoids with functional Purkinje cells. <\/span><i><span style=\"font-weight: 400;\">Cell Stem Cell<\/span><\/i><span style=\"font-weight: 400;\">. 2024 Jan 04;31(1):39-51. PMID: 38181749.<\/span><\/p>\n<p><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Miranda, O., Buth, J., Mitchell, S., Ferando, I., Watanabe, M., Allison, T., Kurdian, I., Fotion, N., Gandal, M., Golshani, P., Plath, K., Lowry, W., Parent, J., Istvan, M., and Novitch, B. Identification of neural oscillations and epileptiform changes in human brain organoids. <\/span><i><span style=\"font-weight: 400;\">Nature Neuroscience<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Oct;24(10):1488-1500. PMID: 34426698.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Allison, T., Langerman, J., Sabri S., Otero-Garcia, M., Lund, A., Huang, J., Wei, X., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Polioudakis, D., Mody, I., Cobos, I., Novitch, BG., Geschwind, DH., Plath, K., and Lowry, W.E. Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis. <\/span><i><span style=\"font-weight: 400;\">Stem Cell Reports<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Oct 12;16(10):2548-2564. PMID: 34506726.<\/span><\/p>\n<p><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Kanuparthi, P., DeFranco, D., Di Maio, R. Transient Muscarinic and Glutamatergic Stimulation of Neural Stem Cells Trigger Acute and Persistent Changes in Differentiation. <\/span><i><span style=\"font-weight: 400;\">Neurobiol of Dis<\/span><\/i><span style=\"font-weight: 400;\">. 2014 Oct 70:252-61. PMCID: PMC4152385.<\/span><\/p>\n<p><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Witchel, S., DeFranco, D. Cooperativity and Complementarity: Synergies in Non-Classical and Classical Glucocorticoid Signaling. <\/span><i><span style=\"font-weight: 400;\">Cell Cycle<\/span><\/i><span style=\"font-weight: 400;\">. 2012 Aug 1 (15):2819-27 PMCID: PMC3419059.<\/span><\/p>\n<p><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Di Maio R., Volonte, D., Galbiati F., Lewis, M., Romero, G., DeFranco, D. Non-genomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. <\/span><i><span style=\"font-weight: 400;\">Proc Natl Acad Sci USA.<\/span><\/i><span style=\"font-weight: 400;\"> 2011 Sep 19. PMCID: PMC3189065.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bales JW, Yan HQ, Ma X, Li Y, <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Dixon CE. The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury. <\/span><i><span style=\"font-weight: 400;\">Exp Neurol.<\/span><\/i><span style=\"font-weight: 400;\"> 201. Epub 2011 Mar 1. PMCID: PMC3110667.<\/span><\/p>\n<p><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. The urgent need to increase support for the NIH\u2019s MD-PhD student fellowships. <\/span><i><span style=\"font-weight: 400;\">Acad Med<\/span><\/i><span style=\"font-weight: 400;\">. 2011 Mar;86(3):277; PubMed PMID: 21346431.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ho, Y*, <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA.*<\/b><\/span><span style=\"font-weight: 400;\">, Knoch ME., Lewis M, Aizenman E, DeFranco DB. Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1\/2-dependent oxidative neuronal cell death. <\/span><i><span style=\"font-weight: 400;\">Mol Pharmacol<\/span><\/i><span style=\"font-weight: 400;\">. 2008 Oct;74(4):1141-51. PMCID: PMC2575064.<\/span><\/p>\n<p><b>*Both authors contributed equally to this work and should be considered co-first authors<\/b><\/p>\n<p><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Tailor, P., Tamura, T., Kaisho, T., Akira S., Ozato, K. Induction of an Anti-Inflammatory Cytokine, IL-10, in Dendritic Cells After Toll-like Receptor Signaling.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Journal of Interferon and Cytokine Research<\/span><\/i><span style=\"font-weight: 400;\">. 2006;26:893-900. PMID:17238832<\/span><br><br><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>PUBLICATIONS Toker, D., McCrimmon, CM., Cao, Q., Pandey, A., Guzman, A., Shriram, A., Hudson, A., Monti, MM., Samarasinghe, RA. Human Brain Assembloids Model Anesthetic-Induced Neural Dynamics. British Journal of Anaesthesia. Accepted July 2026. Guzman, AR., McCrimmon, CM., Toker, D., Novitch, BG., Watanabe, M., Samarasinghe, RA. Protocol for Characterization of Spatiotemporal Network Dynamics in Cortical and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=150"}],"version-history":[{"count":34,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages\/150\/revisions"}],"predecessor-version":[{"id":504,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages\/150\/revisions\/504"}],"wp:attachment":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}