{"id":150,"date":"2023-01-06T00:50:03","date_gmt":"2023-01-06T00:50:03","guid":{"rendered":"http:\/\/localhost:8888\/website\/?page_id=150"},"modified":"2026-10-09T18:52:18","modified_gmt":"2026-10-09T18:52:18","slug":"publications","status":"publish","type":"page","link":"https:\/\/samarasinghelab.com\/?page_id=150","title":{"rendered":"Publications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"150\" class=\"elementor elementor-150\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-407d5f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"407d5f1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0808bc3\" data-id=\"0808bc3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ef284d elementor-widget elementor-widget-heading\" data-id=\"6ef284d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.9.2 - 21-12-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">PUBLICATIONS<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fcf9426 elementor-widget elementor-widget-text-editor\" data-id=\"fcf9426\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.9.2 - 21-12-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">Toker, D., McCrimmon, CM., Cao, Q., Pandey, A., Guzman, A., Shriram, A., Hudson, A., Monti, MM., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. Human brain assembloids as a model of anaesthetic-induced neural dynamics in vitro. <\/span><i><span style=\"font-weight: 400;\">Br J Anaesth<\/span><\/i><span style=\"font-weight: 400;\">. Epub 2026 Sep 30. PMID: 42816290.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">Guzman, AR., McCrimmon, CM., Toker, D., Novitch, BG., Watanabe, M., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. Protocol for Characterization of Spatiotemporal Network Dynamics in Cortical and Hippocampal Assembloids. <\/span><i><span style=\"font-weight: 400;\">STAR Protoc<\/span><\/i><span style=\"font-weight: 400;\">. Epub 2026 Mar 27;7(2):104463. PMID: 41904955.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">McCrimmon, CM.*, Toker, D.*, Pahos, M., Lozano, K., Lin, JJ., Parent, J., Tidball, A., Zheng, J., Molnar, L., Mody, I., Novitch, BG., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. Modeling cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability. <\/span><i><span style=\"font-weight: 400;\">Cell Rep<\/span><\/i><span style=\"font-weight: 400;\">. Epub 2025 Sep 23;44(9):116217.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">Atamian, A., Birtele, M., Hosseini, N., Nguyen, T., Seth, A., Del Dosso, A., Paul, S., Tedeschi, N., Taylor, R., Coba, MP., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Lois, C., and Quadratto, G. Human cerebellar organoids with functional Purkinje cells. <\/span><i><span style=\"font-weight: 400;\">Cell Stem Cell<\/span><\/i><span style=\"font-weight: 400;\">. 2024 Jan 04;31(1):39-51. PMID: 38181749.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Miranda, O., Buth, J., Mitchell, S., Ferando, I., Watanabe, M., Allison, T., Kurdian, I., Fotion, N., Gandal, M., Golshani, P., Plath, K., Lowry, W., Parent, J., Istvan, M., and Novitch, B. Identification of neural oscillations and epileptiform changes in human brain organoids. <\/span><i><span style=\"font-weight: 400;\">Nature Neuroscience<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Oct;24(10):1488-1500. PMID: 34426698.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">Allison, T., Langerman, J., Sabri S., Otero-Garcia, M., Lund, A., Huang, J., Wei, X., <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Polioudakis, D., Mody, I., Cobos, I., Novitch, BG., Geschwind, DH., Plath, K., and Lowry, W.E. Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis. <\/span><i><span style=\"font-weight: 400;\">Stem Cell Reports<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Oct 12;16(10):2548-2564. PMID: 34506726.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Kanuparthi, P., DeFranco, D., Di Maio, R. Transient Muscarinic and Glutamatergic Stimulation of Neural Stem Cells Trigger Acute and Persistent Changes in Differentiation. <\/span><i><span style=\"font-weight: 400;\">Neurobiol of Dis<\/span><\/i><span style=\"font-weight: 400;\">. 2014 Oct 70:252-61. PMCID: PMC4152385.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Witchel, S., DeFranco, D. Cooperativity and Complementarity: Synergies in Non-Classical and Classical Glucocorticoid Signaling. <\/span><i><span style=\"font-weight: 400;\">Cell Cycle<\/span><\/i><span style=\"font-weight: 400;\">. 2012 Aug 1 (15):2819-27 PMCID: PMC3419059.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Di Maio R., Volonte, D., Galbiati F., Lewis, M., Romero, G., DeFranco, D. Non-genomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation. <\/span><i><span style=\"font-weight: 400;\">Proc Natl Acad Sci USA.<\/span><\/i><span style=\"font-weight: 400;\"> 2011 Sep 19. PMCID: PMC3189065.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">Bales JW, Yan HQ, Ma X, Li Y, <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Dixon CE. The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury. <\/span><i><span style=\"font-weight: 400;\">Exp Neurol.<\/span><\/i><span style=\"font-weight: 400;\"> 201. Epub 2011 Mar 1. PMCID: PMC3110667.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">. The urgent need to increase support for the NIH\u2019s MD-PhD student fellowships. <\/span><i><span style=\"font-weight: 400;\">Acad Med<\/span><\/i><span style=\"font-weight: 400;\">. 2011 Mar;86(3):277; PubMed PMID: 21346431.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<span style=\"font-weight: 400;\">Ho, Y*, <\/span><span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA.*<\/b><\/span><span style=\"font-weight: 400;\">, Knoch ME., Lewis M, Aizenman E, DeFranco DB. Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1\/2-dependent oxidative neuronal cell death. <\/span><i><span style=\"font-weight: 400;\">Mol Pharmacol<\/span><\/i><span style=\"font-weight: 400;\">. 2008 Oct;74(4):1141-51. PMCID: PMC2575064.<\/span>\n<\/div>\n\n<div style=\"margin-bottom: 16px;\">\n<b>*Both authors contributed equally to this work and should be considered co-first authors<\/b>\n<\/div>\n\n<div>\n<span style=\"font-weight: 700 !important;\"><b>Samarasinghe, RA<\/b><\/span><span style=\"font-weight: 400;\">., Tailor, P., Tamura, T., Kaisho, T., Akira S., Ozato, K. Induction of an Anti-Inflammatory Cytokine, IL-10, in Dendritic Cells After Toll-like Receptor Signaling. <\/span><i><span style=\"font-weight: 400;\">Journal of Interferon and Cytokine Research<\/span><\/i><span style=\"font-weight: 400;\">. 2006;26:893-900. PMID:17238832<\/span>\n<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>PUBLICATIONS Toker, D., McCrimmon, CM., Cao, Q., Pandey, A., Guzman, A., Shriram, A., Hudson, A., Monti, MM., Samarasinghe, RA. Human brain assembloids as a model of anaesthetic-induced neural dynamics in vitro. Br J Anaesth. Epub 2026 Sep 30. PMID: 42816290. Guzman, AR., McCrimmon, CM., Toker, D., Novitch, BG., Watanabe, M., Samarasinghe, RA. Protocol for Characterization [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=150"}],"version-history":[{"count":52,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages\/150\/revisions"}],"predecessor-version":[{"id":542,"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=\/wp\/v2\/pages\/150\/revisions\/542"}],"wp:attachment":[{"href":"https:\/\/samarasinghelab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}